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Instructors: Prof. Dr. Cristina Cardoso; Dr. of Phil. Henry Herce; Dr. phil. Francesco Natale; Prof. Dr. Ulrike Nuber
Event type:
Lecture
Org-unit: Dept. 10 - Biology
Displayed in timetable as:
10-12-0101-vl
Subject:
Crediting for:
Language of instruction:
Englisch
Min. | Max. participants:
- | -
Course Contents:
The lecture is based on research publications on stem cell biology and epigenetics. In particular the following topics are presented and discussed: replication of the (epi) genome; gene expression, reprogramming and lineage conversion, epigenetics and chromatin.
Literature:
General cell biology text books, e.g.:
• Alberts, Molecular Biology of the Cell
• Lodish, Molecular Cell Biology
• Pollard and Earnshaw, Cell Biology
Developmental Biology e.g.
• Scott F. Gilbert
Epigenetics text books, e.g.:
• Allis et al; Epigenetics
• Misteli and Spector; The Nucleus
• Cook; Principles of Nuclear Structure and Function
Internet material:
• Databases (http://www.ncbi.nlm.nih.gov/sites/entrez; www.ensembl.org)
• Light Microscopy (http://www.microscopy.fsu.edu/primer/index.html)
Preconditions:
Advanced knowledge in cell biology, molecular biology, molecular genetics and biochemistry.
Official Course Description:
To gain basic understanding of epigenetic mechanisms. To understand the relevance of maintaining as well as changing the epigenetic landscape and transcription factor hierarchies for the stability of cell types, for the reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) and for direct cell lineage conversion/trans differentiation. To present research publications and to critically evaluate published research data in the field of stem cell biology and epigenetics. To be able to design cell and molecular biological experiments and to analyze, interpret and present experimental results.
Online Offerings:
all relevant information can be found on Moodle
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